jo lab
Cardiovascular Mechanobiology and Nanomedicine

Publications

SELECTED RECENT PUBLICATIONS (from 130publications) .

For the complete list click here

  1. Rathan S, Ankeny C, Arjunon S, Ferdous Z, Kumar S, Fernandez Esmerats J, Heath JM, Nerem RM, Yoganathan AP, Jo H. Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis. Sci Rep. 2016 May 6;6:25397. doi: 10.1038/srep25397

  2. Kheirolomoom A., Kim C., Seo J., Kumar S., Son D., Gagnon K., Ingham E., Ferrara K., and Jo H. . Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE–/– Mice, ACS Nano 2015 9 (9), 8885-8897

  3. Dunn J, Thabet S, Jo H. Flow-dependent epigenetic DNA methylation in endothelial gene expression and atherosclerosis. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1562-9. doi: 10.1161/ATVBAHA.115.305042. Epub 2015 May 7. PubMed PMID: 25953647

  4. Dunn J, Simmons R, Thabet S, Jo H. The role of epigenetics in the endothelial cell shear stress response and atherosclerosis. Int J Biochem Cell Biol pii: S1357-2725(15)00122-3. doi: 10.1016/j.biocel.2015.05.001. PubMed PMID: 25979369.

  5. Schuermann, Jo H, Brandes, R. Micro-CT technique is well suited for documentation of remodeling processes in murine carotid arteries. PLoS One. 2015 Jun 18;10(6):e0130374. doi: 10.1371/journal.pone.0130374. eCollection 2015. PubMed PMID: 26086218; PubMed Central PMCID: PMC4472757.

  6. Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin N, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y. Mechano-Sensitive PPAP2B Regulates Endothelial Responses to Athero-Relevant Hemodynamic Forces. Circ Res. 2015 Jul 31;117(4):e41-53. doi: 10.1161/CIRCRESAHA.117.306457. Epub 2015 Jun 1. PubMed PMID: 26034042; PubMed Central PMCID: PMC4522239.

  7. Kanthi Y, Hyman MC, Liao H, Baek AE, Visovatti SH, Sutton NR, Goonewardena SN, Neral MK, Jo H, Pinsky DJ. Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis. J Clin Invest. 2015 Aug 3;125(8):3027-36. doi: 10.1172/JCI79514. Epub 2015 Jun 29. PubMed PMID: 26121751

  8. Kang DH, Choi M, Chang S, Lee MY, Lee DJ, Choi K, Park J, Han EC, Hwang D, Kwon K, Jo H, Choi C, Kang SW. Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response. PLoS One. 2015 Aug 25;10(8):e0133845. doi:

  9. Kheirolomoom A, Kim CW, Seo JW, Kumar S, Son DJ, Gagnon MK, Ingham ES, Ferrara KW, Jo H. Multi-Functional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE-/- Mice. ACS Nano. 2015 Aug 26. [Epub ahead of print] PubMed PMID: 26308181.10.1371/journal.pone.0133845. eCollection 2015. PubMed PMID: 26305474.

  10. Sandeep Kumar, Chan Woo Kim, Rachel D Simmons, Hanjoong Jo,  (2014). “Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis Mechanosensitive Athero-miRs.” Arteriosclerosis, Thrombosis, and Vascular Biology 34(10): 2206-2216.

  11. Sandeep Kumar, Chan Woo Kim, Dong Ju Son, Chih Wen Ni, Hanjoong Jo, (2014). “Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo.” Scientific Data

  12. Chih-Wen Ni, Sandeep Kumar, Casey J Ankeny, Hanjoong Jo, (2014). “Development of immortalized mouse aortic endothelial cell lines.” Vascular cell 6(1): 1-10.

  13. Dunn, J., Qiu, H., Kim, S., Jjingo, D., Hoffman, R., Kim, C.W., Jang, I., Son, D.J., Kim, D., Pan, C., et al. 2014. Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. J Clin Invest 124:3187-3199.

  14. D.J. Son, S. K., W. Takabe, C.W. Kim, C.W. Ni, N.A. Grill, I. Jang, S. Kim, W. Kim, S.W. Kim, A. Baker, J.W. S, K. Ferrara, H. Jo. The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nature Communications, doi:10.1038/ncomms4000 (2013).

  15.  Tarbell JM, Shi ZD, Dunn J, Jo H. Fluid Mechanics, Arterial Disease, and Gene Expression. Annu. Rev. Fluid Mech, 2014; 46:591-614. DOI: 10.1146/annurev-fluid-010313-141309

  16. Sorescu GP, Song, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassègue B, Griendling KK, and Jo H. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.  Circ Res 2004;95:773-9.

  17. Miriyala S, Nieto MCG, Harrison DG, Dikalov S, and Jo H.  Bone morphogenic protein 4 induces hypertension by a mechanism involving endothelial dysfunction mediated by NADPH oxidases in C57BL/6 and ApoE-deficient mice. Circulation, 2006;113:2818-2825.

  18. Platt MO, Ankeny R, and Jo H. Laminar shear stress inhibits cathepsin L-dependent gelatinase and elastase activities in endothelial cells. Arterioscler Thromb Vasc Biol. 2006;26:1784-90.

  19. Sykes MC, Mowbray AL, and Jo H.  Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in TNFa-induced cell death.  Circ Res. 2007: 100, 152-154.

  20. San Martin A, Gongora MC, Harrison, D, Jo H, Joseph G, Lassegue B,  Dikalova AE, Taylor WT, Aleman M, Brown KA, and Griendling KK. Reactive oxygenspecies-selective regulation of aortic inflammatory gene expression in type 2 diabetes. Am J Physiol Heart, 2007: 292:H2073-2082.

  21. Chang* K, Weiss D, Suo J, Vega JD, Giddens D, Taylor WR, and Jo H.  Bone morphogenic protein (BMP) antagonists are co-expressed with BMP4 in endothelial cells exposed to unstable flow in vitro, in mouse aortas and in human coronary arteries- Role of BMP antagonists in inflammation and atherosclerosis.  Circulation 2007;116:1258-1266.  *Accompanied by an Editorial.  Circulation2007;116:1221.

  22. Song H, Mowbray AL, and Jo, H. Emerging Role of IGF-1R in Stretch-Induced Neointimal Hyperplasia in Venous Graft. Arterioscler Thromb Vasc Biol. 2007; 100(2):152-4.

  23. Tressel SL, Huang RP, Tomsen N, Jo H.  Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2-dependent mechanism.  Arterioscler Thromb Vasc Biol. 2007; 27:2150-6.

  24. Mowbray A, Rhee SG, Kang SW, and Jo H. Laminar shear stress upregulates peroxiredoxins (PRX) in endothelial cells – PRX 1 as a mechanosensitive antioxidant.  J Biol Chem. 2008; 283(3):1622-7.

  25. Rhee WJ, Santangelo P, Jo, H, and Bao, G. Target Accessibility and Signal Specificity in Live-cell Detection of BMP-4 mRNA Using Molecular Beacons.  Nucleic Acid Research 2008 36(5):e30.

  26. Kim J, Park J, Choi S, Chi SG, Mowbray AL, Jo H, Park H. X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival. Circ Res. 2008;102:896-904.

  27. Tressel SL, Kim H, Ni C-W, Chang K, Velasquez-Castano JC, Taylor WR, Yoon Y-S, Jo H.Angiopoietin-2 Stimulates Blood Flow Recovery after Femoral Artery Occlusion by Inducing Inflammation and Arteriogenesis.  Arterioscler Thromb Vasc Biol. 2008; 28:1989-95.

  28. Mun K, An SM, Park HY, Jo H, Boo YC. Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells.  Am J Physiol Heart 2008, 295(5):H1966-73.

  29. Sucosky P, Elhammali A, Balachandran KB, Jo H*, and Yoganathan AP*. Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4 and TGF-b1 dependent pathway.  Arterioscler Thromb Vasc Biol. 2009:29(2):254-60.

  30. Conway DE, Sakurai Y, Weiss D, Vega JD, Taylor WR, Jo H, Eskin SG, Marcus CB, McIntire LV. Expression of CYP1A1 and CYP1B1 in human endothelial cells: Regulation by fluid shear stress.Cardiovasc Res. 2009 81(4):669-77.

  31. Balachandran K, Sucosky P, Jo H., Yoganathan AP. Elevated cyclic stretch alaters matrix remodeling in aortic valve cusps – Implications for degenerative aortic valve disease. Am J Physiology Heart & Circ.2009 296(3):H756-64.

  32. Reed RE, Potter B, Smith E, Jadhav R, Villalta P, Jo H, Rocic P. Redox-sensitive Akt and Src Regulate Coronary Collateral Growth in the Metabolic Syndrome. Am J Physiol. 2009, 296:H1811-21.

  33. Nam D*, Ni C-W*, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison D, Giddens D, and Jo H. Partial carotid ligation is a model of acutely induced disturbed flow which results in rapid endothelial dysfunction and atherosclerosis. Am J Physiol Heart Circ Physiol. 2009, 297:H1535-43.

  34. Yin W, Jo H, Voit EO. Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammation. Ann Biomed Eng. 2010;38:291-307

  35. Rhee WJ, Ni CW, Zheng Z, Chang K, Jo H, Bao G. Hur regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. 2010;107:6858-6863

  36. Ni CW, Qiu H, Rezvan A, Kwon K, Nam D, Son DJ, Visvader JE, Jo H. Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow.Blood. 2010;116:e66-73

  37. Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison DG, Giddens DP, Jo H. A model of disturbed flow-induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of rna isolation from carotid endothelium. J Vis Exp. 2010

  38. Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H, Harrison DG, Chen W. Gtp cyclohydrolase i phosphorylation and interaction with gtp cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Circ Res. 2010;106:328-336.

  39. Kim J, Ahn S, Ko YG, Boo YC, Chi SG, Ni CW, Go YM, Jo H, Park H. X-linked inhibitor of apoptosis protein controls alpha5-integrin-mediated cell adhesion and migration. Am J Physiol Heart Circ Physiol. 2010;299:H300-309

  40. Conway DE, Lee S, Eskin SG, Shah AK, Jo H, McIntire LV. Endothelial metallothionein expression and intracellular free zinc levels are regulated by shear stress. Am J Physiol Cell Physiol. 2010;299:C1461-1467

  41. Bond AR, Ni CW, Jo H, Weinberg PD. Intimal cushions and endothelial nuclear elongation around mouse aortic branches and their spatial correspondence with patterns of lipid deposition. Am J Physiol Heart Circ Physiol. 2010;298:H536-544

  42. Hemodynamics and Mechanobiology of Endothelium, Edited by Hsiai TK, Blackman B, and Jo H. World Scientific Books, ISBN: 978-981-4280-41-9. 2010.

  43. Balachandran K, Sucosky P, Jo H, Yoganathan AP. Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner. Am J Pathol. 2010;177:49-57

  44. Rezvan A, Ni CW, Alberts-Grill N, Jo H. Animal, in vitro, and ex vivo models of flow-dependent atherosclerosis: Role of oxidative stress. Antioxid Redox Signal. 2011;15(5):1433-48. PMCID:PMC3144429

  45. Boo YC, Mun GI, Tressel SL, Jo H. Detection of low levels of nitric oxide using an electrochemical sensor. Methods Mol Biol. 2011;704:81-89

  46. Ferdous Z, Jo H, Nerem RM. Differences in valvular and vascular cell responses to strain in osteogenic media. Biomaterials. 2011;32:2885-2893

  47. Ni CW, Qiu H, Jo H. Microrna-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells. Am J Physiol Heart Circ Physiol. 2011; 300(5):H1762-9. PMCID:PMC3094086

  48. Jadhav R, Dodd T, Smith E, Bailey E, Delucia AL, Russell JC, Madison R, Potter BJ, Walsh K, Jo H,Rocic P. Angiotensin type i receptor blockade in conjunction with enhanced akt activation restores coronary collateral growth in the metabolic syndrome. Am J Physiol Heart Circ Physiol. 2011; 300(5):H1938-49.

  49. Thayer P, Balachandran K, Rathan S, Yap CH, Arjunon S, Jo H, Yoganathan AP. The effects of combined cyclic stretch and pressure on the aortic valve interstitial cell phenotype. Ann Biomed Eng. 2011; 39(6):1654-67

  50. Noguchi N, Jo H. Redox going with vascular shear stress. Antioxid Redox Signal. 2011, 15:1367-68. PMCID:PMC3144424

  51. Li L, Chen W, Rezvan A, Jo H, Harrison DG. Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow. Arterioscler Thromb Vasc Biol. 2011; 31(7):1547-54

  52. Takabe W, Albert-Grill N, Jo. H. Disturbed flow: p53 sumoylation in endothelial cell turnover.  J Cell Biology 2011;193(5):805-7. PMCID:PMC3105545

  53. Ankeny RF, Thourani VH, Weiss D, Vega DJ, Taylor WR, Nerem RM, Jo H.  Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves- Association with low BMP antagonists and SMAD6. PLoS One. 2011;6(6):e20969. PMCID:PMC3115968

  54. Holliday CJ, Ankeny RF, Jo H*, Nerem RM. Discovery of Shear- and Side-specific mRNAs and miRNAs in Human Aortic Valvular Endothelial Cells. Am J Physiol Heart Circ Physiol. 2011. *Corresponding author. PMCID:PMC3191100

  55. Park JG, Yoo JY, Jeong SJ, Choi JH, Lee MR, Lee MN, Lee JH, Kim HC, Jo H, Yu DY, Kang SW, Rhee SG, Lee MH, Oh GT. Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice by inhibition of immune cell infiltration. Circ Res. 2011;109(7):739-49.

  56. Alberts-Grill N, Rezvan A, Son DJ, Qiu H, Kim CW, Kemp ML, Weyand CM, Jo H. Dynamic immune cell accumulation during flow-induced atherogenesis in mouse carotid artery: An expanded flow cytometry method. Arterioscler Thromb Vasc Biol. 2012. PMCID:PMC3336102

  57. Fazeli G, Stopper H, Schinzel R, Ni C, Jo H, and Nicole Schupp. Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4.  Mutagen. In Press

  58. Huh JY, Son D, Lee Y, Lee J, Kim B, Lee HM, Jo H, Choi C,  Ha H, Chung M. 8-hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation. Free Rad Biol Med 2012 in Press.

  59. Ankeny RF, Ankeny CJ, Nerem RM, Jo H. Maturing EPCs into endothelial cells: May the force be with the EPCs. Am J Phsiol Cell Physiolo 2012, in press.

  60. Son DJ, Kim SY, Han SS, Kim CW, Kumar S, Park BS, Lee SE, Yun YP, Jo H* and Park HP. Piperlongumine, an alkaloid compound from Piper Longum L., inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by supporessing PDGF signaling.  BiochemBiophys Res Comm, in press. 2012. * Corresponding author